In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

Huntington's disease (HD), caused by a CAG repeat expansion in the huntingtin (HTT) gene, is characterized by abnormal protein aggregates and motor and cognitive dysfunction. Htt protein is ubiquitously expressed, but the striatal medium spiny neuron (MSN) is most susceptible to dysfunction and...

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Bibliographic Details
Main Authors: Thomas, Elizabeth A., Coppola, Giovanni, Tang, Bin, Kuhn, Alexandre, Kim, SoongHo, Geschwind, Daniel H., Brown, Timothy B., Luthi-Carter, Ruth, Ehrlich, Michelle E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043657/
https://ncbi.nlm.nih.gov/pubmed/21177255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq548
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