In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

Samankaltaisia teoksia

• Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function
  Tekijä: Ho Kim, Soong, et al.
  Julkaistu: (2011)
• Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse
  Tekijä: Brown, Timothy B., et al.
  Julkaistu: (2008)
• Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits
  Tekijä: DiFiglia, M., et al.
  Julkaistu: (2007)
• Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease
  Tekijä: Tang, Bin, et al.
  Julkaistu: (2011)
• Short-Term Striatal Gene Expression Responses to Brain-Derived Neurotrophic Factor Are Dependent on MEK and ERK Activation
  Tekijä: Gokce, Ozgun, et al.
  Julkaistu: (2009)