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Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease
R6/2 transgenic mice with expanded CAG repeats (>300) have a surprisingly prolonged disease progression and longer lifespan than prototypical parent R6/2 mice (carrying 150 CAGs), however, the mechanism of this phenotype amelioration is unknown. We compared gene expression profiles in the striatu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079804/ https://ncbi.nlm.nih.gov/pubmed/21334439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.02.008 |
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