Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function

HD (Huntington's disease) is characterized by dysfunction and death of striatal MSNs (medium-sized spiny neurons). Excitotoxicity, transcriptional dysregulation and mitochondrial abnormalities are among the mechanisms that are proposed to play roles in HD pathogenesis. To determine the extent o...

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Detalhes bibliográficos
Main Authors: Ho Kim, Soong, Thomas, Carlos A, André, Véronique M, Cummings, Damian M, Cepeda, Carlos, Levine, Michael S, Ehrlich, Michelle E
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Neurochemistry 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155197/
https://ncbi.nlm.nih.gov/pubmed/21542802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20110009
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