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Modeling Ca(2+) Dynamics of Mouse Cardiac Cells Points to a Critical Role of SERCA's Affinity for Ca(2+)
The SERCA2a isoform of the sarco/endoplasmic reticulum Ca(2+) pumps is specifically expressed in the heart, whereas SERCA2b is the ubiquitously expressed variant. It has been shown previously that replacement of SERCA2a by SERCA2b in mice (SERCA2(b/b) mice) results in only a moderate functional impa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3043210/ https://ncbi.nlm.nih.gov/pubmed/21354394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.024 |
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