An N-terminal Ca(2+)-binding motif regulates the secretory pathway Ca(2+)/Mn(2+)-transport ATPase SPCA1

The Ca(2+)/Mn(2+) transport ATPases 1a and 2 (SPCA1a/2) are closely related to the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) and are implicated in breast cancer and Hailey–Hailey skin disease. Here, we purified the human SPCA1a/2 isoforms from a yeast recombinant expression system and compa...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Jialin, Smaardijk, Susanne, Mattelaer, Charles-Alexandre, Pamula, Filip, Vandecaetsbeek, Ilse, Vanoevelen, Jo, Wuytack, Frank, Lescrinier, Eveline, Eggermont, Jan, Vangheluwe, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514643/
https://ncbi.nlm.nih.gov/pubmed/30923126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006250
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