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Structural basis for the high Ca(2+) affinity of the ubiquitous SERCA2b Ca(2+) pump

Sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA) Ca(2+) transporters pump cytosolic Ca(2+) into the endoplasmic reticulum, maintaining a Ca(2+) gradient that controls vital cell functions ranging from proliferation to death. To meet the physiological demand of the cell, SERCA activity is regulated...

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Autors principals: Vandecaetsbeek, Ilse, Trekels, Mieke, De Maeyer, Marc, Ceulemans, Hugo, Lescrinier, Eveline, Raeymaekers, Luc, Wuytack, Frank, Vangheluwe, Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774012/
https://ncbi.nlm.nih.gov/pubmed/19846779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906797106
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