Structures of the heart specific SERCA2a Ca(2+)‐ATPase

The sarcoplasmic/endoplasmic reticulum Ca(2+)‐ATPase 2a (SERCA2a) performs active reuptake of cytoplasmic Ca(2+) and is a major regulator of cardiac muscle contractility. Dysfunction or dysregulation of SERCA2a is associated with heart failure, while restoring its function is considered as a therape...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Sitsel, Aljona, De Raeymaecker, Joren, Drachmann, Nikolaj Düring, Derua, Rita, Smaardijk, Susanne, Andersen, Jacob Lauwring, Vandecaetsbeek, Ilse, Chen, Jialin, De Maeyer, Marc, Waelkens, Etienne, Olesen, Claus, Vangheluwe, Peter, Nissen, Poul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396164/
https://ncbi.nlm.nih.gov/pubmed/30777856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100020
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