Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance

Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody-driven antigenic...

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Autores principales: Hensley, Scott E., Das, Suman R., Gibbs, James S., Bailey, Adam L., Schmidt, Loren M., Bennink, Jack R., Yewdell, Jonathan W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043005/
https://ncbi.nlm.nih.gov/pubmed/21364978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015190
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