AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

Mitogen-activated protein kinase (MAPK) cascades propagate a variety of cellular activities1. Processive relay of signals through RAF–MEK–ERK modulates cell growth and proliferation2,3. Signalling through this ERK cascade is frequently amplified in cancers, and drugs such as sorafenib (which is pres...

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Hauptverfasser: Smith, F. Donelson, Langeberg, Lorene K., Cellurale, Cristina, Pawson, Tony, Morrison, Deborah K., Davis, Roger J., Scott, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042953/
https://ncbi.nlm.nih.gov/pubmed/21102438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2130
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