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AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

Mitogen-activated protein kinase (MAPK) cascades propagate a variety of cellular activities1. Processive relay of signals through RAF–MEK–ERK modulates cell growth and proliferation2,3. Signalling through this ERK cascade is frequently amplified in cancers, and drugs such as sorafenib (which is pres...

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Detalhes bibliográficos
Main Authors: Smith, F. Donelson, Langeberg, Lorene K., Cellurale, Cristina, Pawson, Tony, Morrison, Deborah K., Davis, Roger J., Scott, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042953/
https://ncbi.nlm.nih.gov/pubmed/21102438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2130
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