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Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination

Recent studies recognize that Hypocretin system (also known as Orexin) plays a critical role in sleep/wake disorders and feeding behaviors. However, little is known about the regulation of the Hypocretin system. It is also known that tumor necrosis factor alpha (TNF-α) is involved in regulation of s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhan, Shuqin, Cai, Guo-Qiang, Zheng, Anni, Wang, Yuping, Jia, Jianping, Fang, Haotian, Yang, Youfeng, Hu, Meng, Ding, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042489/
https://ncbi.nlm.nih.gov/pubmed/21094253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.11.003
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