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Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF- alpha) production and found that the drug enhances the degradation of TNF-alpha mRNA. Thus, the half-life of the molecule was reduced from approximately 30 to approximately...
Uloženo v:
| Médium: | Artigo |
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| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
1993
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2191046/ https://ncbi.nlm.nih.gov/pubmed/8496685 |
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