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Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy

OBJECTIVES: The cause of hypocretin cell loss in human narcolepsy–cataplexy is unknown but has been suggested to be neurodegenerative in nature. To test this hypothesis, we evaluated the remaining hypocretin cells in human narcolepsy brains for the presence of aggregated protein inclusions, gliosis,...

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Autors principals: Honda, M, Arai, T, Fukazawa, M, Honda, Y, Tsuchiya, K, Salehi, A, Akiyama, H, Mignot, E
Format: Artigo
Idioma:Inglês
Publicat: American Academy of Neurology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730798/
https://ncbi.nlm.nih.gov/pubmed/19687452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181b2a6af
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