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Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy

OBJECTIVES: The cause of hypocretin cell loss in human narcolepsy–cataplexy is unknown but has been suggested to be neurodegenerative in nature. To test this hypothesis, we evaluated the remaining hypocretin cells in human narcolepsy brains for the presence of aggregated protein inclusions, gliosis,...

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書誌詳細
主要な著者: Honda, M, Arai, T, Fukazawa, M, Honda, Y, Tsuchiya, K, Salehi, A, Akiyama, H, Mignot, E
フォーマット: Artigo
言語:Inglês
出版事項: American Academy of Neurology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730798/
https://ncbi.nlm.nih.gov/pubmed/19687452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181b2a6af
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