Hypocretin Receptor Expression in Canine and Murine Narcolepsy Models and in Hypocretin-Ligand Deficient Human Narcolepsy

STUDY OBJECTIVE: To determine whether hypocretin receptor gene (hcrtR1 and hcrtR2) expression is affected after long-term hypocretin ligand loss in humans and animal models of narcolepsy. DESIGN: Animal and human study. We measured hcrtR1 and hcrtR2 expression in the frontal cortex and pons using th...

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Detalhes bibliográficos
Main Authors: Mishima, Kazuo, Fujiki, Nobuhiro, Yoshida, Yasushi, Sakurai, Takeshi, Honda, Makoto, Mignot, Emmanuel, Nishino, Seiji
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2008
Assuntos:
Hypocretin Receptor Expression in Narcolepsy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542958/
https://ncbi.nlm.nih.gov/pubmed/18714784
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