Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour

Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF‐α) is an important neuroinflammation mediator. Here, we examined the effects of TNF‐α treatment on hypocretin expression in vivo and behaviour in mice. TNF‐α decreased hypocretin...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zhan, Shuqin, Che, Pulin, Zhao, Xue‐ke, Li, Ning, Ding, Yan, Liu, Jianghong, Li, Spring, Ding, Karyn, Han, Lynn, Huang, Zhaoyang, Wu, Liyong, Wang, Yuping, Hu, Meng, Han, Xiaosi, Ding, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787512/
https://ncbi.nlm.nih.gov/pubmed/31386303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14566
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