Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour

Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF‐α) is an important neuroinflammation mediator. Here, we examined the effects of TNF‐α treatment on hypocretin expression in vivo and behaviour in mice. TNF‐α decreased hypocretin...

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Vydáno v:J Cell Mol Med
Hlavní autoři: Zhan, Shuqin, Che, Pulin, Zhao, Xue‐ke, Li, Ning, Ding, Yan, Liu, Jianghong, Li, Spring, Ding, Karyn, Han, Lynn, Huang, Zhaoyang, Wu, Liyong, Wang, Yuping, Hu, Meng, Han, Xiaosi, Ding, Qiang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787512/
https://ncbi.nlm.nih.gov/pubmed/31386303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14566
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