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CDK prevents Mcm2–7 helicase loading by inhibiting Cdt1 interaction with Orc6
In Saccharomyces cerevisiae cells, B-type cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits, Orc2 and Orc6, to inhibit helicase loading. We show that helicase loading by ORC is inhibited by two distinct CDK-dependent mechanisms. Independent of phosphorylation, bind...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042159/ https://ncbi.nlm.nih.gov/pubmed/21289063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2011511 |
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