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Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2–7 helicases
Eukaryotic origins of replication are selected by loading a head-to-head double hexamer of the Mcm2–7 replicative helicase around origin DNA. Cdt1 plays an essential but transient role during this event; however, its mechanism of action is unknown. Through analysis of Cdt1 mutations, we demonstrate...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243627/ https://ncbi.nlm.nih.gov/pubmed/22045335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.394 |
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