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Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an important biopharmaceutical. In this study, the biological activity of BoNT/A1 is compared to that of BoNT/A2 using neuronal...

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Detalhes bibliográficos
Main Authors: Pier, Christina L., Chen, Chen, Tepp, William H., Lin, Guangyun, Janda, Kim D., Barbieri, Joseph T., Pellett, Sabine, Johnson, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041152/
https://ncbi.nlm.nih.gov/pubmed/21126520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.11.045
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