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Cyclin T1 overexpression induces malignant transformation and tumor growth

Human PTEFb is a protein kinase composed by CDK9 and Cyclin T that controls the elongation phase of RNA Pol II. This complex also affects the activation and differentiation program of lymphoid cells. In this study we found that several head and neck tumor cell lines overexpress PTEFb. We also establ...

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Autori principali: Moiola, Cristian, De Luca, Paola, Gardner, Kevin, Vazquez, Elba, De Siervi, Adriana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040930/
https://ncbi.nlm.nih.gov/pubmed/20714219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.15.12526
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