Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

To determine if Neu is dominant over transforming growth factor β (TGF-β), we crossed mouse mammary tumor virus (MMTV)-Neu mice with MMTV-TGF-β1(S223/225) mice expressing active TGF-β1 in the mammary gland. Bigenic (NT) and Neu-induced mammary tumors developed with a similar latency. The bigenic tum...

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Detalhes bibliográficos
Main Authors: Muraoka, Rebecca S., Koh, Yasuhiro, Roebuck, L. Renee, Sanders, Melinda E., Brantley-Sieders, Dana, Gorska, Agnieszka E., Moses, Harold L., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262670/
https://ncbi.nlm.nih.gov/pubmed/14612410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8691-8703.2003
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