Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

TGF-βs are potent inhibitors of epithelial cell proliferation. However, in established carcinomas, autocrine/paracrine TGF-β interactions can enhance tumor cell viability and progression. Thus, we studied the effect of a soluble Fc:TGF-β type II receptor fusion protein (Fc:TβRII) on transgenic and t...

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Detalhes bibliográficos
Main Authors: Muraoka, Rebecca S., Dumont, Nancy, Ritter, Christoph A., Dugger, Teresa C., Brantley, Dana M., Chen, Jin, Easterly, Evangeline, Roebuck, L. Renee, Ryan, Sarah, Gotwals, Philip J., Koteliansky, Victor, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151012/
https://ncbi.nlm.nih.gov/pubmed/12070302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15234
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