Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

Chimeric oncoproteins resulting from fusion of MLL to a wide variety of partnering proteins cause biologically distinctive and clinically aggressive acute leukemias. However, the mechanism of MLL-mediated leukemic transformation is not fully understood. Dot1, the only known histone H3 lysine 79 (H3K...

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Autori principali: Chang, Ming-Jin, Wu, Hongyu, Achille, Nicholas J., Reisenauer, Mary Rose, Chou, Chau-Wen, Zeleznik-Le, Nancy J., Hemenway, Charles S., Zhang, Wenzheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040779/
https://ncbi.nlm.nih.gov/pubmed/21159644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3294
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