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Dot1a-AF9 Complex Mediates Histone H3 Lys-79 Hypermethylation and Repression of ENaCα in an Aldosterone-sensitive Manner

Aldosterone is a major regulator of epithelial Na(+) absorption and acts in large part through induction of the epithelial Na(+) channel (ENaC) gene in the renal collecting duct. We previously identified Dot1a as an aldosterone early repressed gene and a repressor of ENaCα transcription through medi...

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Sonraí Bibleagrafaíochta
Main Authors: Zhang, Wenzheng, Xia, Xuefeng, Reisenauer, Mary Rose, Hemenway, Charles S., Kone, Bruce C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015183/
https://ncbi.nlm.nih.gov/pubmed/16636056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M601903200
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