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Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription
Aldosterone is a major regulator of Na(+) absorption and acts by activating the mineralocorticoid receptor (MR) to stimulate the epithelial Na(+) channel (ENaC). MR(−/−) mice exhibited pseudohypoaldosteronism type 1 (hyponatremia, hyperkalemia, salt wasting, and high levels of aldosterone) and died...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Physiological Society
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3840248/ https://ncbi.nlm.nih.gov/pubmed/24026182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00202.2013 |
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