Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription

Aldosterone is a major regulator of Na(+) absorption and acts by activating the mineralocorticoid receptor (MR) to stimulate the epithelial Na(+) channel (ENaC). MR(−/−) mice exhibited pseudohypoaldosteronism type 1 (hyponatremia, hyperkalemia, salt wasting, and high levels of aldosterone) and died...

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Main Authors: Zhang, Xi, Zhou, Qiaoling, Chen, Lihe, Berger, Stefan, Wu, Hongyu, Xiao, Zhou, Pearce, David, Zhou, Xiaodong, Zhang, Wenzheng
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840248/
https://ncbi.nlm.nih.gov/pubmed/24026182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00202.2013
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