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An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene
The epithelial Na(+) channel subunit-α (αENaC) of the distal nephron is essential for salt balance. We previously demonstrated that the histone methyltransferase Dot1a and its protein partner Af9 basally repress αENaC transcription in mouse inner medullary collecting duct type 3 (mIMCD3) cells and l...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566494/ https://ncbi.nlm.nih.gov/pubmed/23152297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00537.2011 |
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