Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy). Such tau aggregate is found to be hyperphosphorylated and often proteolyticall...

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Hlavní autoři: Cheng Liu, Ming, Kobeissy, Firas, Zheng, Wenrong, Zhang, Zhiqun, Hayes, Ronald L, Wang, Kevin KW
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Neurochemistry 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040574/
https://ncbi.nlm.nih.gov/pubmed/21359008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100012
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