Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy). Such tau aggregate is found to be hyperphosphorylated and often proteolyticall...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cheng Liu, Ming, Kobeissy, Firas, Zheng, Wenrong, Zhang, Zhiqun, Hayes, Ronald L, Wang, Kevin KW
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Neurochemistry 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040574/
https://ncbi.nlm.nih.gov/pubmed/21359008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100012
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