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Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy). Such tau aggregate is found to be hyperphosphorylated and often proteolyticall...

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Detalhes bibliográficos
Main Authors: Cheng Liu, Ming, Kobeissy, Firas, Zheng, Wenrong, Zhang, Zhiqun, Hayes, Ronald L, Wang, Kevin KW
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Neurochemistry 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040574/
https://ncbi.nlm.nih.gov/pubmed/21359008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100012
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