Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury

Transactivation response DNA-binding protein 43 (TDP-43) proteinopathy has recently been reported in chronic traumatic encephalopathy, a neurodegenerative condition linked to prior history of traumatic brain injury (TBI). While TDP-43 appears to be vulnerable to proteolytic modifications under neuro...

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Hlavní autoři: Yang, Zhihui, Lin, Fan, Robertson, Claudia S, Wang, Kevin K W
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158661/
https://ncbi.nlm.nih.gov/pubmed/24917042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.105
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