Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration

Frontotemporal lobar degeneration (FTLD) is among the most prevalent dementias of early-onset. Pathologically, FTLD presents with tauopathy or TAR DNA-binding protein 43 (TDP-43) proteinopathy. A biallelic mouse model of FTLD was produced on a mix FVB/129SVE background overexpressing wild-type human...

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Publicado no:J Neurosci
Main Authors: Kukreja, L., Shahidehpour, R., Kim, G., Keegan, J., Sadleir, K.R., Russell, T., Csernansky, J., Mesulam, M., Vassar, R.J., Wang, L., Dong, H., Geula, C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031584/
https://ncbi.nlm.nih.gov/pubmed/29807909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1836-17.2018
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