Distribution of TDP-43 Pathology in Hippocampal Synaptic Relays Suggests Transsynaptic Propagation in Frontotemporal Lobar Degeneration

Hyperphosphorylation, nuclear depletion, and aggregation of TDP-43 in ubiquitinated inclusions is a hallmark of frontotemporal lobar degeneration (FTLD-TDP). Evidence of potential spread of TDP-43 along synaptic connections in the human is largely limited to qualitative and semiquantitative observat...

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Publicat a:J Neuropathol Exp Neurol
Autors principals: Jamshidi, Pouya, Kim, Garam, Shahidehpour, Ryan K, Bolbolan, Kabriya, Gefen, Tamar, Bigio, Eileen H, Mesulam, Marek-Marsel, Geula, Changiz
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241939/
https://ncbi.nlm.nih.gov/pubmed/32388566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlaa029
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