Direct method for detecting small quantities of hepatitis B virus DNA in serum and plasma using the polymerase chain reaction.

Serum components inhibit DNA polymerase, thereby obviating direct detection of serum viral DNA sequences by the polymerase chain reaction (PCR). This has necessitated extraction of nucleic acid from sera before performing PCR and has resulted in loss of sensitivity. By adsorbing virus to a solid sur...

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Foilsithe in:	J Clin Invest
Príomhchruthaitheoirí:	Zeldis, J B, Lee, J H, Mamish, D, Finegold, D J, Sircar, R, Ling, Q, Knudsen, P J, Kuramoto, I K, Mimms, L T
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	American Society for Clinical Investigation 1989
Ábhair:	Research Article
Rochtain ar líne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2808703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114326
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