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Stabilization of the Single-Chain Fragment Variable by an Interdomain Disulfide Bond and Its Effect on Antibody Affinity
The interdomain instability of single-chain fragment variable (scFv) might result in intermolecular aggregation and loss of function. In the present study, we stabilized H4—an anti-aflatoxin B(1) (AFB(1)) scFv—with an interdomain disulfide bond and studied the effect of the disulfide bond on antibod...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Molecular Diversity Preservation International (MDPI)
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039938/ https://ncbi.nlm.nih.gov/pubmed/21339972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12010001 |
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