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Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability
The structure of insulin, a glucose homeostasis-controlling hormone, is highly conserved in all vertebrates and stabilized by three disulfide bonds. Recently, we designed a novel insulin analogue containing a fourth disulfide bond located between positions A10-B4. The N-terminus of insulin's B-...
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| Publicado en: | Protein Sci |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4420526/ https://ncbi.nlm.nih.gov/pubmed/25627966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2649 |
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