A Live Attenuated Listeria Monocytogenes Vaccine Vector Expressing SIV Gag Is Safe and Immunogenic in Macaques and Can Be Administered Repeatedly

Listeria monocytogenes (Lm) is known to induce strong cellular immune responses. We constructed a live-attenuated Lm vector, Lmdd-BdopSIVgag, which encodes SIVmac239 gag. Intragastric (i.g.) administration of 3×10(12) bacteria to rhesus macaques was safe and induced anti-Gag cellular but no humoral...

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Detalhes bibliográficos
Main Authors: Sciaranghella, Gaia, Lakhashe, Samir, Ayash-Rashkovsky, Mila, Mirshahidi, Saied, Siddappa, Nagadenahalli B., Novembre, Francis J., Velu, Vijayakumar, Amara, Rama Rao, Zhou, Chenghui, Li, Sufen, Li, Zhongxia, Frankel, Fred R., Ruprecht, Ruth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039419/
https://ncbi.nlm.nih.gov/pubmed/21070847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.10.072
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