Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges

We sought to induce primate immunodeficiency virus-specific cellular and neutralizing antibody (nAb) responses in rhesus macaques (RM) through a bimodal vaccine approach. RM were immunized intragastrically (i.g.) with the live-attenuated Listeria monocytogenes (Lm) vector Lmdd-BdopSIVgag encoding SI...

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Autors principals: Lakhashe, Samir K., Velu, Vijayakumar, Sciaranghella, Gaia, Siddappa, Nagadenahalli B., DiPasquale, Janet M., Hemashettar, Girish, Yoon, John K., Rasmussen, Robert A., Yang, Feng, Lee, Sandra J., Montefiori, David C., Novembre, Francis J., Villinger, François, Amara, Rama Rao, Kahn, Maria, Hu, Shiu-Lok, Li, Sufen, Li, Zhongxia, Frankel, Fred R., Robert-Guroff, Marjorie, Johnson, Welkin E., Lieberman, Judy, Ruprecht, Ruth M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154722/
https://ncbi.nlm.nih.gov/pubmed/21693155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.06.017
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