Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

BACKGROUND: A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due to multiple HIV-1 quasispecies circulating in the human population worldwide, he...

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Bibliografiske detaljer
Main Authors: Sholukh, Anton M, Byrareddy, Siddappa N, Shanmuganathan, Vivekanandan, Hemashettar, Girish, Lakhashe, Samir K, Rasmussen, Robert A, Watkins, Jennifer D, Vyas, Hemant K, Thorat, Swati, Brandstoetter, Tania, Mukhtar, Muhammad M, Yoon, John K, Novembre, Francis J, Villinger, Francois, Landucci, Gary, Forthal, Donald N, Ratcliffe, Sarah, Tuero, Iskra, Robert-Guroff, Marjorie, Polonis, Victoria R, Bilska, Miroslawa, Montefiori, David C, Johnson, Welkin E, Ertl, Hildegund C, Ruprecht, Ruth M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905655/
https://ncbi.nlm.nih.gov/pubmed/24444350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-8
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