Development of a tier 1 R5 clade C simian–human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis

BACKGROUND: While some recently transmitted HIV clade C (HIV-C) strains exhibited tier 1 neutralization phenotypes, most were tier 2 strains (J Virol 2010; 84:1439). Because induction of neutralizing antibodies (nAbs) through vaccination against tier 2 viruses has proven difficult, we have generated...

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Bibliographic Details
Main Authors: Siddappa, Nagadenahalli B., Hemashettar, Girish, Wong, Yin Ling, Lakhashe, Samir, Rasmussen, Robert A., Watkins, Jennifer D., Novembre, Francis J., Villinger, François, Else, James G., Montefiori, David C., Ruprecht, Ruth M.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285499/
https://ncbi.nlm.nih.gov/pubmed/21044092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0684.2010.00454.x
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