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Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis
In unstressed cells, the p53 tumor suppressor is highly unstable. DNA damage and other forms of cellular stress rapidly stabilize and activate p53. This process is regulated by a complex array of post-translational modifications that are dynamically deposited onto p53. Recent studies show that these...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039376/ https://ncbi.nlm.nih.gov/pubmed/21148320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184663 |
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