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Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis

In unstressed cells, the p53 tumor suppressor is highly unstable. DNA damage and other forms of cellular stress rapidly stabilize and activate p53. This process is regulated by a complex array of post-translational modifications that are dynamically deposited onto p53. Recent studies show that these...

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Hlavní autoři: Mellert, Hestia S., Stanek, Timothy J., Sykes, Stephen M., Rauscher, Frank J., Schultz, David C., McMahon, Steven B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039376/
https://ncbi.nlm.nih.gov/pubmed/21148320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184663
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