A rare DNA contact mutation in cancer confers p53 gain‐of‐function and tumor cell survival via TNFAIP8 induction

The p53 tumor suppressor gene encodes a sequence‐specific transcription factor. Mutations in the coding sequence of p53 occur frequently in human cancer and often result in single amino acid substitutions (missense mutations) in the DNA binding domain (DBD), blocking normal tumor suppressive functio...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Monteith, Jessica A., Mellert, Hestia, Sammons, Morgan A., Kuswanto, Laudita A., Sykes, Stephen M., Resnick-Silverman, Lois, Manfredi, James J., Berger, Shelley L., McMahon, Steven B.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423199/
https://ncbi.nlm.nih.gov/pubmed/27341992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.05.007
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