A rare DNA contact mutation in cancer confers p53 gain‐of‐function and tumor cell survival via TNFAIP8 induction

The p53 tumor suppressor gene encodes a sequence‐specific transcription factor. Mutations in the coding sequence of p53 occur frequently in human cancer and often result in single amino acid substitutions (missense mutations) in the DNA binding domain (DBD), blocking normal tumor suppressive functio...

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Publicat a:Mol Oncol
Autors principals: Monteith, Jessica A., Mellert, Hestia, Sammons, Morgan A., Kuswanto, Laudita A., Sykes, Stephen M., Resnick-Silverman, Lois, Manfredi, James J., Berger, Shelley L., McMahon, Steven B.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423199/
https://ncbi.nlm.nih.gov/pubmed/27341992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.05.007
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