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Acetylation of the p53 DNA binding domain regulates apoptosis induction.
The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here we describe a previously unknown post-translational modification of the DNA-binding domain of p53. This modification, acetylation of lysine 120, occurs rapidly after DNA damage and is catalyzed by the MYST fami...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766330/ https://ncbi.nlm.nih.gov/pubmed/17189187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.11.026 |
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