Acetylation of the p53 DNA binding domain regulates apoptosis induction.

The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here we describe a previously unknown post-translational modification of the DNA-binding domain of p53. This modification, acetylation of lysine 120, occurs rapidly after DNA damage and is catalyzed by the MYST fami...

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Bibliografiske detaljer
Main Authors: Sykes, Stephen M., Mellert, Hestia S., Holbert, Marc A., Li, Keqin, Marmorstein, Ronen, Lane, William S., McMahon, Steven B.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766330/
https://ncbi.nlm.nih.gov/pubmed/17189187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.11.026
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