The T Cell Receptor β-Chain Second Complementarity Determining Region Loop (CDR2β) Governs T Cell Activation and Vβ Specificity by Bacterial Superantigens

Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing structural information indicates that diverse bacterial SAgs all uniformly engage the Vβ second complementarity dete...

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Autori principali: Rahman, A. K. M. Nur-ur, Bonsor, Daniel A., Herfst, Christine A., Pollard, Fraser, Peirce, Michael, Wyatt, Aaron W., Kasper, Katherine J., Madrenas, Joaquín, Sundberg, Eric J., McCormick, John K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039367/
https://ncbi.nlm.nih.gov/pubmed/21127057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189068
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