Neutralization of Multiple Staphylococcal Superantigens by a Single-Chain Protein Consisting of Affinity-Matured, Variable Domain Repeats

Staphylococcus aureussecretes various toxins that act as superantigens by stimulating a large fraction of the host’s T cells. Toxin binding to variable domains of T cell receptor β chains (Vβ) leads to massive release of inflammatory molecules and potentially to toxic shock syndrome (TSS). Previousl...

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Bibliografiska uppgifter
Huvudupphovsmän: Yang, Xi, Buonpane, Rebecca A., Moza, Beenu, Rahman, A. K. M. Nur-ur, Wang, Ningyan, Schlievert, Patrick M., McCormick, John K., Sundberg, Eric J., Kranz, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649774/
https://ncbi.nlm.nih.gov/pubmed/18522504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/589776
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