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Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery

Translation initiation in eukaryotes involves more than a dozen protein factors. Alterations in six factors have been found to reduce the fidelity of start codon recognition by the ribosomal preinitiation complex in yeast, a phenotype referred to as Sui(−). No small molecules are known that affect t...

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Hlavní autoři: Takacs, Julie E., Neary, Timothy B., Ingolia, Nicholas T., Saini, Adesh K., Martin-Marcos, Pilar, Pelletier, Jerry, Hinnebusch, Alan G., Lorsch, Jon R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039144/
https://ncbi.nlm.nih.gov/pubmed/21220547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2475211
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