Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge

Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIV(mac251) challenges, exhibited elite control of viremia over 6½ years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIV(smE6...

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Huvudupphovsmän: Patterson, L. Jean, Daltabuit-Test, Mara, Xiao, Peng, Zhao, Jun, Hu, William, Wille-Reece, Ulrike, Brocca-Cofano, Egidio, Kalyanaraman, V.S., Kalisz, Irene, Whitney, Stephen, Lee, Eun Mi, Pal, Ranajit, Montefiori, David C., Dandekar, Satya, Seder, Robert, Roederer, Mario, Wiseman, Roger W., Hirsch, Vanessa, Robert-Guroff, Marjorie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039060/
https://ncbi.nlm.nih.gov/pubmed/21237474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.033
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