Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route

Although priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, followed by HIV/SIV envelope boosting, has proven highly immunogenic, resulting in protection from SIV/simian-human immunodeficiency viru...

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Detalhes bibliográficos
Main Authors: Patterson, L. Jean, Kuate, Seraphin, Daltabuit-Test, Mara, Li, Qingsheng, Xiao, Peng, McKinnon, Katherine, DiPasquale, Janet, Cristillo, Anthony, Venzon, David, Haase, Ashley, Robert-Guroff, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346327/
https://ncbi.nlm.nih.gov/pubmed/22441384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00010-12
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