Immune Targeting of PD-1(hi) Expressing Cells During and Alter Antiretroviral Therapy in SIV-infected Rhesus Macaques

High-level T-cell expression of PD-1 during SIV infection is correlated with impaired proliferation and function. We evaluated the phenotype and distribution of T-cells and Tregs during antiretroviral therapy plus PD-1 modulation (using a B7-DC-Ig fusion protein) and post-ART. Chronically SIV-infect...

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Main Authors: Vargas-Inchaustegui, Diego A., Xiao, Peng, Hogg, Alison E., Demberg, Thorsten, McKinnon, Katherine, Venzon, David, Brocca-Cofano, Egidio, DiPasquale, Janet, Lee, Eun M., Hudacik, Lauren, Pal, Ranajit, Sui, Yongjun, Berzofsky, Jay A., Liu, Linda, Langermann, Solomon, Robert-Guroff, Marjorie
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869407/
https://ncbi.nlm.nih.gov/pubmed/24210124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.09.015
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