Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

The radiotracer [(11)C]N-desmethyl-loperamide (dLop) images the in vivo function of P-glycoprotein (P-gp), a transporter that blocks the entry of drugs that are substrates into brain. When P-gp is inhibited, [(11)C]dLop, a potent opiate agonist, enters and becomes trapped in the brain. This trapping...

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Main Authors: Kannan, Pavitra, Brimacombe, Kyle R., Kreisl, William C., Liow, Jeih-San, Zoghbi, Sami S., Telu, Sanjay, Zhang, Yi, Pike, Victor W., Halldin, Christer, Gottesman, Michael M., Innis, Robert B., Hall, Matthew D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038699/
https://ncbi.nlm.nih.gov/pubmed/21262843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014641108
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